Methanol Extract of <i>Thottea siliquosa</i> (Lam.) Ding Hou Leaves Inhibits Carrageenan- and Formalin-Induced Paw Edema in Mice
Aneeta Renny,
Jameema Sidhic,
Alby Tom,
Aswathi Moothakoottil Kuttithodi,
Joice Tom Job,
Rajakrishnan Rajagopal,
Ahmed Alfarhan,
Arunaksharan Narayanankutty
Affiliations
Aneeta Renny
Division of Cell and Molecular Biology, PG & Research Department of Zoology, St. Joseph’s College (Autonomous), Calicut (Affiliated to University of Calicut) 673008, India
Jameema Sidhic
Phytochemistry and Pharmacology Division, PG & Research Department of Botany, St. Joseph’s College (Autonomous), Calicut 673008, India
Alby Tom
Division of Cell and Molecular Biology, PG & Research Department of Zoology, St. Joseph’s College (Autonomous), Calicut (Affiliated to University of Calicut) 673008, India
Aswathi Moothakoottil Kuttithodi
Division of Cell and Molecular Biology, PG & Research Department of Zoology, St. Joseph’s College (Autonomous), Calicut (Affiliated to University of Calicut) 673008, India
Joice Tom Job
Division of Cell and Molecular Biology, PG & Research Department of Zoology, St. Joseph’s College (Autonomous), Calicut (Affiliated to University of Calicut) 673008, India
Rajakrishnan Rajagopal
Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia
Ahmed Alfarhan
Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia
Arunaksharan Narayanankutty
Division of Cell and Molecular Biology, PG & Research Department of Zoology, St. Joseph’s College (Autonomous), Calicut (Affiliated to University of Calicut) 673008, India
Inflammation is a physiological condition that when unattended causes serious health concerns over the long term. Several phytocompounds have emerged as promising sources of anti-inflammatory agents. Thottea siliquosa is a traditional medicine for inflammatory and toxicity insults; however, this has not been scientifically confirmed. The purpose of this study is to evaluate the anti-inflammatory properties of T. siliquosa methanol leaf extract in a mouse model. This study investigates the anti-inflammatory activities of a plant extract obtained from leaves of T. siliquosa (TSE) with a focus on carrageenan- and formalin-induced paw oedema in mice. The extract’s efficacy was assessed using well-established inflammation models, and the results showed a considerable reduction in paw edema in both cases. In the case of carrageenan model TSE at 50 mg/kg showed a 53.0 ± 2.5% reduction in edema, while those treated with TSM at 100 mg/kg exhibited a 60.0 ± 1.8% reduction (p T. siliquosa extract exerts anti-inflammatory effects in animals and is possibly mediated through the combined effects of these phytochemicals.
