International Brazilian Journal of Urology (Dec 2015)

Clinical significance of serum and urinary HER2/neu protein levels in primary non-muscle invasive bladder cancer

  • Ozgur Arikan,
  • Asýf Yýldýrým,
  • Banu Ýsbilen,
  • Cengiz Canakci,
  • Gokhan Atýs,
  • Cenk Gurbuz,
  • Bulent Erol,
  • Ferruh Kemal Ýsman,
  • Seyma Ozkanli,
  • Turhan Caskurlu

DOI
https://doi.org/10.1590/S1677-5538.IBJU.2014.0628
Journal volume & issue
Vol. 41, no. 6
pp. 1080 – 1087

Abstract

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Objective: We aimed to compare serum and urinary HER2/neu levels between healthy control group and patients with non-muscle invasive bladder cancer. Additionally, we evaluated relationship of HER2/neu levels with tumor stage, grade, recurrence and progression. Materials and Methods: Fourty-four patients with primary non-muscle invasive bladder tumors (Group 2) and 40 healthy control group (Group 1) were included the study. Blood and urinary samples were collected from all patients and HER2/neu levels were measured by ELISA method. Blood and urinary HER2/neu levels and additionally, ratio of urinary HER2/neu levels to urinary creatinine levels were recorded. Demographic data and tumor characteristics were recorded. Results: Mean serum HER2/neu levels were similar between two groups and statistically significant difference wasn't observed. Urinary HER2/neu levels were significantly higher in group 2 than group 1. Ratio of urinary HER2/neu to urinary creatinine was significantly higher in group 2 than group 1, (p=0,021). Serum and urinary HER2/ neu levels were not associated with tumor stage, grade, recurrence and progression while ratio of urinary HER2/neu to urinary creatinin levels were significantly higher in high-grade tumors. HER2/neu, the sensitivity of the test was found to be 20.5%, and the specificity was 97.5%, also for the urinary HER2/neu/urinary creatinine ratio, the sensitivity and specificity of the test were found to be 31.8% and 87.5%, respectively. Conclusions: Urinary HER2/neu and ratio of urinary creatinine urine were significantly higher in patients with bladder cancer compared to healthy subjects. Large series and controlled studies are needed for use as a tumor marker.

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