MicroRNAs involve in bicuspid aortic aneurysm: pathogenesis and biomarkers

Abstract

Abstract The incidence of bicuspid aortic valves (BAV) is high in the whole population, BAV-related thoracic aortic aneurysm (TAA) is accompanied by many adverse vascular events. So far, there are two key points in dealing with BAV-related TAA. First is fully understanding on its pathogenesis. Second is optimizing surgical intervention time. This review aims to illustrate the potential role of miRNAs in both aspects, that is, how miRNAs are involved in the occurrence and progression of BAV-related TAA, and the feasibilities of miRNAs as biomarkers.

Keywords

• miRNA
• Aneurysm
• Bicuspid aortic valve
• Mechanism
• Biomarker