Allosteric coupling between α-rings of the 20S proteasome

Zanlin Yu; Yadong Yu; Feng Wang; Alexander G. Myasnikov; Philip Coffino; Yifan Cheng

doi:10.1038/s41467-020-18415-7

Nature Communications (Sep 2020)

Allosteric coupling between α-rings of the 20S proteasome

Zanlin Yu,
Yadong Yu,
Feng Wang,
Alexander G. Myasnikov,
Philip Coffino,
Yifan Cheng

Affiliations

Zanlin Yu: Department of Biochemistry and Biophysics, University of California
Yadong Yu: Department of Biochemistry and Biophysics, University of California
Feng Wang: Department of Biochemistry and Biophysics, University of California
Alexander G. Myasnikov: Department of Biochemistry and Biophysics, University of California
Philip Coffino: Laboratory of Cellular Biophysics, Rockefeller University
Yifan Cheng: Department of Biochemistry and Biophysics, University of California

DOI: https://doi.org/10.1038/s41467-020-18415-7
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 11

Abstract

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The 26S proteasome is a protein degradation machine composed of a 20S core particle (CP) flanked at one or both ends by a 19S ATPase regulatory particle (RP). Here the authors reconstitute asymmetric archaeal proteasomes and reveal allosteric coupling between the conformations of gates in the α-rings positioned at opposite ends of the CP, which modulates RP assembly and substrate entry.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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