Plasma total homocysteine levels and other biochemical parameters in Algerian patients with deep vein thrombosis

Abstract

We studied total plasma homocysteine levels (tHcy) in Algerian patients with a deep venous thrombosis (DVT). We measured tHcy levels in a total of 99 subjects enrolled in this study, including 40 patients with DVT and 59 healthy controls. The mean tHcy level in the patients was 12.62±8.7 μmol/L and that in the controls was 10.2± 2.1 μmol/L. In a univariate regression model, tHcy concentrations were inversely correlated with triglycerides (TG) (r=–0.358; p=0.023) and total cholesterol (TC) (r=–0.454; p=0.003) concentrations. Logistic regression analysis showed that tHcy after adjustment was significantly associated with the following factors: TC (p=0.003) and TG (p=0.023). The analysis in DVT patients showed that variables independently associated with tHcy were TC [odds ratio (OR) 2.1, 95% confidence interval (CI) 1.7–2.6], low-density lipoprotein cholesterol (OR 2.0, 95% CI 1.6–2.5), creatinine (OR 2.2, 95% CI 1.7–2.6), and smoking (OR 2.1, 95% CI 1.7–2.5). In conclusion, these results indicate that tHcy levels and other biochemical parameters are important determinant factors for DVT diseases in Algerian patients.

Keywords

• algerian
• deep venous thrombosis
• homocysteine
• lipid profile