Heatstroke-induced acute kidney injury and the innate immune system

Hiroyasu Goto; Manabu Kinoshita; Naoki Oshima

doi:10.3389/fmed.2023.1250457

Frontiers in Medicine (Aug 2023)

Heatstroke-induced acute kidney injury and the innate immune system

Hiroyasu Goto,
Manabu Kinoshita,
Naoki Oshima

Affiliations

Hiroyasu Goto: Department of Nephrology and Endocrinology, National Defense Medical College, Tokorozawa, Japan
Manabu Kinoshita: Department of Immunology and Microbiology, National Defense Medical College, Tokorozawa, Japan
Naoki Oshima: Department of Nephrology and Endocrinology, National Defense Medical College, Tokorozawa, Japan

DOI: https://doi.org/10.3389/fmed.2023.1250457
Journal volume & issue: Vol. 10

Abstract

Read online

Heatstroke can cause multiple organ failure and systemic inflammatory response syndrome as the body temperature rises beyond the body’s ability to regulate temperature in a hot environment. Previous studies have indicated that heatstroke-induced acute kidney injury (AKI) can lead to chronic kidney disease. Therefore, there is an urgent need to elucidate the mechanism of heatstroke-induced AKI and to establish methods for its prevention and treatment. Recent reports have revealed that innate immunity, including neutrophils, macrophages, lymphocytes, and mast cells, is deeply involved in heat-induced AKI. In this review, we will discuss the roles of each immune cell in heat-induced renal injury and their potential therapeutic use.

Published in Frontiers in Medicine

ISSN: 2296-858X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Medicine (General)
Website: http://www.frontiersin.org/journals/medicine

About the journal

Abstract

Keywords