Репродуктивная эндокринология (May 2022)
Preserving reproductive health before the first pregnancy
Abstract
Research objective: to evaluate the effectiveness of drugs based on decamethoxine for the treatment of inflammatory diseases of genital organs in adolescent girls entering reproductive age. Materials and methods. The study included 96 patients aged 17–19 years who lived an irregular sexual life. The diagnosis of vulvovaginal infection was verified based on clinical and laboratory data. All patients with vulvovaginal infection received Decasan solution 50–100 ml three times a day in the form of irrigation of the external genitalia for the daytime sanitation and Gynodek vaginal gel 5 ml once at night for 7 days, which provided a night exposure of the antiseptic component and created an environment for the restoration of vaginal lactoflora. The effectiveness of treatment was assessed by the results of clinical and bacteriological examination before and after treatment. The criteria for the effectiveness of treatment were complete clinical and bacterial sanitation. Results. According to the results of the microbiological study, all patients were divided into 3 groups: group I consisted of 36 patients with nonspecific vulvovaginitis, group II – 28 adolescent girls with vulvovaginal candidiasis, group III – 32 patients with mixed bacterial-candidiasis infection. The clinical efficacy of therapy was 95.8%: in group I – 94.4%, in group II – 96.4%, in group III – 96.9%. Bacteriological examination, carried out 2 weeks after the end of the course of treatment, confirmed the effectiveness of therapy in 94.4% of adolescent girls with nonspecific vulvovaginitis, in 89.3% with vulvovaginal candidiasis and in 87.5% with mixed bacterial-candidiasis infection. Conclusions. Topical treatment of inflammatory genital diseases in adolescent girls entering reproductive age is effective, safe and can be considered the therapy of choice. Therapy with drugs based on decamethoxine (Decasan and Gynodek) is highly effective in mono- and mixed vulvovaginal infections, which contributes to the preservation of the reproductive health of adolescent girls at the stage of entering reproductive age.
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