Nature Communications (Oct 2017)

A novel Fer/FerT targeting compound selectively evokes metabolic stress and necrotic death in malignant cells

  • Yoav Elkis,
  • Moshe Cohen,
  • Etai Yaffe,
  • Shirly Satmary-Tusk,
  • Tal Feldman,
  • Elad Hikri,
  • Abraham Nyska,
  • Ariel Feiglin,
  • Yanay Ofran,
  • Sally Shpungin,
  • Uri Nir

DOI
https://doi.org/10.1038/s41467-017-00832-w
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 17

Abstract

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The tyrosine-kinases Fer/FerT associate with the mitochondrial electron transport chain in cancer cells supporting their metabolic reprogramming. Here the authors discover a compound that disrupts Fer /FerT activity and selectively induces cell death of cancer cell lines displaying anti-tumor activity in vivo.