Nature Communications (Oct 2017)
A novel Fer/FerT targeting compound selectively evokes metabolic stress and necrotic death in malignant cells
Abstract
The tyrosine-kinases Fer/FerT associate with the mitochondrial electron transport chain in cancer cells supporting their metabolic reprogramming. Here the authors discover a compound that disrupts Fer /FerT activity and selectively induces cell death of cancer cell lines displaying anti-tumor activity in vivo.