Bone mineral disorder in chronic kidney disease: Klotho and FGF23; cardiovascular implications

Abstract

Cardiovascular factors are one of the main causes of morbidity and mortality in patients with chronic kidney disease. Bone mineral metabolism disorders and inflammation are pathological conditions that involve increased cardiovascular risk in chronic kidney disease. The cardiovascular risk involvement of bone mineral metabolism classical biochemical parameters such as phosphorus, calcium, vitamin D and PTH is well known. The newest markers, FGF23 and klotho, could also be implicated in cardiovascular disease.

Keywords

• Cardiovascular risk
• Chronic kidney disease
• Klotho
• FGF23