Remote control of neural function by X-ray-induced scintillation

Takanori Matsubara; Takayuki Yanagida; Noriaki Kawaguchi; Takashi Nakano; Junichiro Yoshimoto; Maiko Sezaki; Hitoshi Takizawa; Satoshi P. Tsunoda; Shin-ichiro Horigane; Shuhei Ueda; Sayaka Takemoto-Kimura; Hideki Kandori; Akihiro Yamanaka; Takayuki Yamashita

doi:10.1038/s41467-021-24717-1

Nature Communications (Jul 2021)

Remote control of neural function by X-ray-induced scintillation

Takanori Matsubara,
Takayuki Yanagida,
Noriaki Kawaguchi,
Takashi Nakano,
Junichiro Yoshimoto,
Maiko Sezaki,
Hitoshi Takizawa,
Satoshi P. Tsunoda,
Shin-ichiro Horigane,
Shuhei Ueda,
Sayaka Takemoto-Kimura,
Hideki Kandori,
Akihiro Yamanaka,
Takayuki Yamashita

Affiliations

Takanori Matsubara: Department of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University
Takayuki Yanagida: Nara Institute of Science and Technology
Noriaki Kawaguchi: Nara Institute of Science and Technology
Takashi Nakano: Nara Institute of Science and Technology
Junichiro Yoshimoto: Nara Institute of Science and Technology
Maiko Sezaki: International Research Center for Medical Sciences, Kumamoto University
Hitoshi Takizawa: International Research Center for Medical Sciences, Kumamoto University
Satoshi P. Tsunoda: Department of Life Science and Applied Chemistry, Nagoya Institute of Technology
Shin-ichiro Horigane: Department of Neuroscience I, Research Institute of Environmental Medicine, Nagoya University
Shuhei Ueda: Department of Neuroscience I, Research Institute of Environmental Medicine, Nagoya University
Sayaka Takemoto-Kimura: Department of Neuroscience I, Research Institute of Environmental Medicine, Nagoya University
Hideki Kandori: Department of Life Science and Applied Chemistry, Nagoya Institute of Technology
Akihiro Yamanaka: Department of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University
Takayuki Yamashita: Department of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University

DOI: https://doi.org/10.1038/s41467-021-24717-1
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 12

Abstract

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Scintillators emit visible luminescence when irradiated with X-rays and may enable remote optogenetic control of neurons deep in the brain. The authors inject an inorganic scintillator to activate and inhibit midbrain dopamine neurons in freely moving mice by X-ray irradiation to modulate place preference behavior.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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