Nature Communications (Oct 2017)
TRPV4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cells
- Yeranddy A. Alpizar,
- Brett Boonen,
- Alicia Sanchez,
- Carole Jung,
- Alejandro López-Requena,
- Robbe Naert,
- Brecht Steelant,
- Katrien Luyts,
- Cristina Plata,
- Vanessa De Vooght,
- Jeroen A. J. Vanoirbeek,
- Victor M. Meseguer,
- Thomas Voets,
- Julio L. Alvarez,
- Peter W. Hellings,
- Peter H. M. Hoet,
- Benoit Nemery,
- Miguel A. Valverde,
- Karel Talavera
Affiliations
- Yeranddy A. Alpizar
- Department of Cellular and Molecular Medicine, Laboratory for Ion Channel Research, KU Leuven
- Brett Boonen
- Department of Cellular and Molecular Medicine, Laboratory for Ion Channel Research, KU Leuven
- Alicia Sanchez
- Department of Cellular and Molecular Medicine, Laboratory for Ion Channel Research, KU Leuven
- Carole Jung
- Department of Experimental and Health Sciences, Laboratory of Molecular Physiology and Channelopathies, Universitat Pompeu Fabra
- Alejandro López-Requena
- Department of Cellular and Molecular Medicine, Laboratory for Ion Channel Research, KU Leuven
- Robbe Naert
- Department of Cellular and Molecular Medicine, Laboratory for Ion Channel Research, KU Leuven
- Brecht Steelant
- Department of Microbiology and Immunology, Laboratory of Clinical Immunology, KU Leuven
- Katrien Luyts
- Department of Public Health and Care, Laboratory of Environment and Health, KU Leuven
- Cristina Plata
- Department of Experimental and Health Sciences, Laboratory of Molecular Physiology and Channelopathies, Universitat Pompeu Fabra
- Vanessa De Vooght
- Department of Public Health and Care, Laboratory of Environment and Health, KU Leuven
- Jeroen A. J. Vanoirbeek
- Department of Public Health and Care, Laboratory of Environment and Health, KU Leuven
- Victor M. Meseguer
- Instituto de Neurociencias de Alicante, Universidad Miguel Hernández-CSIC
- Thomas Voets
- Department of Cellular and Molecular Medicine, Laboratory for Ion Channel Research, KU Leuven
- Julio L. Alvarez
- Department of Cellular and Molecular Medicine, Laboratory for Ion Channel Research, KU Leuven
- Peter W. Hellings
- Department of Microbiology and Immunology, Laboratory of Clinical Immunology, KU Leuven
- Peter H. M. Hoet
- Department of Public Health and Care, Laboratory of Environment and Health, KU Leuven
- Benoit Nemery
- Department of Public Health and Care, Laboratory of Environment and Health, KU Leuven
- Miguel A. Valverde
- Department of Experimental and Health Sciences, Laboratory of Molecular Physiology and Channelopathies, Universitat Pompeu Fabra
- Karel Talavera
- Department of Cellular and Molecular Medicine, Laboratory for Ion Channel Research, KU Leuven
- DOI
- https://doi.org/10.1038/s41467-017-01201-3
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
LPS is a major component of gram-negative bacterial cell walls, and triggers immune responses in airway epithelium by activating TLR4. Here the authors show that LPS also activates TRPV4, thereby inducing fast defense responses such as nitric oxide production and increased ciliary beating in mice.
