Nature Communications (May 2022)
Genomic dissection of Klebsiella pneumoniae infections in hospital patients reveals insights into an opportunistic pathogen
- Claire L. Gorrie,
- Mirjana Mirčeta,
- Ryan R. Wick,
- Louise M. Judd,
- Margaret M. C. Lam,
- Ryota Gomi,
- Iain J. Abbott,
- Nicholas R. Thomson,
- Richard A. Strugnell,
- Nigel F. Pratt,
- Jill S. Garlick,
- Kerrie M. Watson,
- Peter C. Hunter,
- David V. Pilcher,
- Steve A. McGloughlin,
- Denis W. Spelman,
- Kelly L. Wyres,
- Adam W. J. Jenney,
- Kathryn E. Holt
Affiliations
- Claire L. Gorrie
- Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Mirjana Mirčeta
- Microbiology Unit, Alfred Pathology Service, The Alfred Hospital
- Ryan R. Wick
- Department of Infectious Diseases, Central Clinical School, Monash University
- Louise M. Judd
- Department of Infectious Diseases, Central Clinical School, Monash University
- Margaret M. C. Lam
- Department of Infectious Diseases, Central Clinical School, Monash University
- Ryota Gomi
- Department of Infectious Diseases, Central Clinical School, Monash University
- Iain J. Abbott
- Microbiology Unit, Alfred Pathology Service, The Alfred Hospital
- Nicholas R. Thomson
- Wellcome Sanger Institute
- Richard A. Strugnell
- Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Nigel F. Pratt
- Infectious Diseases Clinical Research Unit, The Alfred Hospital
- Jill S. Garlick
- Infectious Diseases Clinical Research Unit, The Alfred Hospital
- Kerrie M. Watson
- Department of Infectious Diseases, Central Clinical School, Monash University
- Peter C. Hunter
- Aged Care, Caulfield Hospital, Alfred Health
- David V. Pilcher
- Intensive Care Unit, The Alfred Hospital
- Steve A. McGloughlin
- Intensive Care Unit, The Alfred Hospital
- Denis W. Spelman
- Microbiology Unit, Alfred Pathology Service, The Alfred Hospital
- Kelly L. Wyres
- Department of Infectious Diseases, Central Clinical School, Monash University
- Adam W. J. Jenney
- Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne
- Kathryn E. Holt
- Department of Infectious Diseases, Central Clinical School, Monash University
- DOI
- https://doi.org/10.1038/s41467-022-30717-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Klebsiella pneumoniae is an opportunistic pathogen of increasing public health concern due to the prevalence of antimicrobial resistance. Here, the authors provide insight into the resistance profiles, bacterial genome features and virulence genes, in a year-long prospective study of K. pneumoniae clinical isolates.
