Pathogens (Dec 2021)

Association between <i>Interleukin-1</i> Polymorphisms and Susceptibility to Dental Peri-Implant Disease: A Meta-Analysis

  • Hady Mohammadi,
  • Mehrnoush Momeni Roochi,
  • Masoud Sadeghi,
  • Ata Garajei,
  • Hosein Heidar,
  • Ali Aghaie Meybodi,
  • Mohsen Dallband,
  • Sarton Mostafavi,
  • Melina Mostafavi,
  • Mojtaba Salehi,
  • Jyothi Tadakamadla,
  • Dena Sadeghi-Bahmani,
  • Serge Brand

DOI
https://doi.org/10.3390/pathogens10121600
Journal volume & issue
Vol. 10, no. 12
p. 1600

Abstract

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Background and objective: Interleukins (ILs), as important biochemical mediators, control the host response to inflammation and are associated with bone resorption. In the present meta-analysis, we investigated the association between IL−1 polymorphisms and susceptibility to dental peri-implant disease (PID). Materials and methods: We searched Web of Science, Cochrane Library, Scopus, and PubMed/Medline databases for studies published until 9 September2021, without any restrictions. We calculated the crude OR and 95% confidence intervals (CI) to estimate the associations between IL−1 polymorphisms and PID risk in the five genetic models. We further performed the subgroup analysis, sensitivity analysis, meta-regression, trial sequential analysis, and calculated the publication bias. Results: Out of 212 retrieved records, sixteen articles were used in the meta-analysis. There was no association between IL−1A (–889), IL−1B (−511), IL−1B (+3953), and IL−1RN (VNTR) polymorphisms and the risk of dental PIDs, but there was an increased risk of IL−1B (+3954) in the patients with PIDs. In addition, an association of the composite genotype of IL−1A (−889)/IL−1B (+3953) was observed with the risk of PIDs, but not for the composite genotype of IL−1A (−889)/IL−1B (+3954). The publication year, the ethnicity, sample size, and the outcome were significantly influenced pooled estimates of some genetic models. Trial sequential analysis showed the lack of sufficient sample sizes in the studies. Conclusions: Among IL−1 polymorphisms evaluated in the meta-analysis, the composite genotype of IL−1A (−889)/IL−1B (+3953) and IL−1B (+3954) were the only polymorphisms associated with the risk of PID. The T allele and CT genotype of IL−1B (+3954) polymorphism were also associated with an elevated risk of PID.

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