Propylthiouracil-induced necrotizing vasculitis

Abstract

Propylthiouracil (PTU)-induced vasculitis is a rare antineutrophilic cytoplasmic antibody-associated vasculitis involving small vessels. The patients are often present with constitutional symptoms such as skin rash, fever, sore throat, and joint pain, and rarely with systemic symptoms such as muscle pain, weakness, weight loss, conjunctival, and mucosal irritation. Early diagnosis with the help of clinical findings, laboratory and serological markers, discontinuation of PTU, and immunosuppressive treatments are beneficial. In this study, a case of necrotizing vasculitis after PTU is presented, and the literature is reviewed.

Keywords

• antineutrophilic cytoplasmic antibody
• propylthiouracil
• skin necrosis
• vasculitis