Dysembryoplastic Neuroepithelial Tumor (Dnet) in a Young Female: A Rare Case Presentation

Abstract

Dysembryoplastic neuroepithelial tumor (DNET) is a recently described, morphologically unique, and surgically curable low grade brain tumor which is included in the WHO CNS classification as neuronal and mixed neuronal glial tumor. It is usually seen in children and young adults. This entity first described by Damas-Duport in 1998 is usually non-recurring with an excellent prognosis. We present a case of 30 year old female experiencing seizures with well defined space occupying lesion in the frontal region of brain. Contrast enhanced Magnetic Resonance Imaging was done which revealed well defined multilobulated solid cystic mass lesion in cortical/ subcortical region of left frontal lobe. Histological features suggested dysembryoplastic neuroepithelial tumor which was subsequently confirmed on immunohistochemistry by GFAP and S-100 positivity. The principal differential diagnosis is oligodendrogliomas and gangliogliomas. Patient did not receive any adjuvant therapy post operatively and showed no signs of residual disease or recurrence on magnetic resonance imaging during follow up. Patient is on phenytoin for prophylaxis of seizures.

Keywords

• dysembryoplastic neuroepithelial tumor, histology, neuronal-glial, gfap