IL-36 promotes anti-viral immunity by boosting sensitivity to IFN-α/β in IRF1 dependent and independent manners

Peng Wang; Ana M. Gamero; Liselotte E. Jensen

doi:10.1038/s41467-019-12318-y

Nature Communications (Oct 2019)

IL-36 promotes anti-viral immunity by boosting sensitivity to IFN-α/β in IRF1 dependent and independent manners

Peng Wang,
Ana M. Gamero,
Liselotte E. Jensen

Affiliations

Peng Wang: Department of Microbiology and Immunology, Temple University Lewis Katz School of Medicine
Ana M. Gamero: Department of Medical Genetics and Molecular Biochemistry, Temple University Lewis Katz School of Medicine
Liselotte E. Jensen: Department of Microbiology and Immunology, Temple University Lewis Katz School of Medicine

DOI: https://doi.org/10.1038/s41467-019-12318-y
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 17

Abstract

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Herpes simplex virus-1 (HSV-1) suppresses the induction of interferon to evade antiviral immunity. Here, Wang et al. show that during HSV-1 infection, IL-36 increases cellular sensitivity to interferon through induction of IRF1 and the interferon receptor.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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