BMC Medicine (Feb 2024)

Mid- and long-term risk of atrial fibrillation among breast cancer surgery survivors

  • Yong-Moon Mark Park,
  • Wonyoung Jung,
  • Yohwan Yeo,
  • Sang Hyun Park,
  • Michael G. Fradley,
  • Sindhu J. Malapati,
  • Tushar Tarun,
  • Vinay Raj,
  • Hong Seok Lee,
  • Tasneem Z. Naqvi,
  • Ronda S. Henry-Tillman,
  • Jawahar L. Mehta,
  • Mario Schootman,
  • Benjamin C. Amick,
  • Kyungdo Han,
  • Dong Wook Shin

DOI
https://doi.org/10.1186/s12916-024-03308-z
Journal volume & issue
Vol. 22, no. 1
pp. 1 – 14

Abstract

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Abstract Background The risk of incident atrial fibrillation (AF) among breast cancer survivors, especially for younger women, and cancer treatment effects on the association remain unclear. This study aimed to investigate the risk of AF among breast cancer survivors and evaluate the association by age group, length of follow-up, and cancer treatment. Methods Using data from the Korean Health Insurance Service database (2010–2017), 113,232 women newly diagnosed with breast cancer (aged ≥ 18 years) without prior AF history who underwent breast cancer surgery were individually matched 1:5 by birth year to a sample female population without cancer (n = 566,160) (mean[SD] follow-up, 5.1[2.1] years). Sub-distribution hazard ratios (sHRs) and 95% confidence intervals (CIs) considering death as a competing risk were estimated, adjusting for sociodemographic factors and cardiovascular/non-cardiovascular comorbidities. Results BCS had a slightly increased AF risk compared to their cancer-free counterparts (sHR 1.06; 95% CI 1.00–1.13), but the association disappeared over time. Younger BCS (age 65 years. Use of anthracyclines was associated with increased AF risk among BCS (sHR 1.57; 95% CI 1.28–1.92), which was more robust in younger BCS (sHR 1.94; 95% CI 1.40–2.69 in those aged ≤ 50 years). Conclusions Our findings suggest that younger BCS had an elevated risk of incident AF, regardless of the length of follow-up. Use of anthracyclines may be associated with increased mid-to-long-term AF risk among BCS. Graphical Abstract

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