The enigma of RIPK1 in the liver: More than just a kinase

Abstract

Receptor interacting protein kinase 1 (RIPK1) represents a key molecule in cell death. Here, we discuss our recent data on RIPK1 in liver injury and hepatocellular carcinoma development and put these into relation to previous experimental findings to underpin that it exerts opposing kinase-dependent and kinase independent functions in liver cells.

Keywords

• acetaminophen
• apap
• cona
• concanavalin a
• hcc
• hepatocarcinogenesis
• rip1
• traf2