Differential effects of prediction error and adaptation along the auditory cortical hierarchy during deviance processing
Insa Schlossmacher,
Jacky Dilly,
Ina Protmann,
David Hofmann,
Torge Dellert,
Marie-Luise Roth-Paysen,
Robert Moeck,
Maximilian Bruchmann,
Thomas Straube
Affiliations
Insa Schlossmacher
Institute of Medical Psychology and Systems Neuroscience, University of Münster, Münster 48149, Germany; Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience, University of Münster, Münster 48149, Germany; Corresponding author at: Institute of Medical Psychology and Systems Neuroscience, University of Münster, Von-Esmarch-Strasse 52, Münster 48149, Germany.
Jacky Dilly
Institute of Medical Psychology and Systems Neuroscience, University of Münster, Münster 48149, Germany
Ina Protmann
Institute of Medical Psychology and Systems Neuroscience, University of Münster, Münster 48149, Germany
David Hofmann
Institute of Medical Psychology and Systems Neuroscience, University of Münster, Münster 48149, Germany
Torge Dellert
Institute of Medical Psychology and Systems Neuroscience, University of Münster, Münster 48149, Germany; Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience, University of Münster, Münster 48149, Germany
Marie-Luise Roth-Paysen
Institute of Medical Psychology and Systems Neuroscience, University of Münster, Münster 48149, Germany
Robert Moeck
Institute of Medical Psychology and Systems Neuroscience, University of Münster, Münster 48149, Germany
Maximilian Bruchmann
Institute of Medical Psychology and Systems Neuroscience, University of Münster, Münster 48149, Germany; Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience, University of Münster, Münster 48149, Germany
Thomas Straube
Institute of Medical Psychology and Systems Neuroscience, University of Münster, Münster 48149, Germany; Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience, University of Münster, Münster 48149, Germany
Neural mismatch responses have been proposed to rely on different mechanisms, including prediction error-related activity and adaptation to frequent stimuli. However, the hierarchical cortical structure of these mechanisms is unknown. To investigate this question, we recorded hemodynamic responses while participants (N = 54) listened to an auditory oddball sequence as well as a suited control condition. In addition to effects in sensory processing areas (Heschl's gyrus, superior temporal gyrus (STG)), we found several distinct clusters that indexed deviance processing in frontal and parietal regions (anterior cingulate cortex/supplementary motor area (ACC/SMA), inferior parietal lobule (IPL), anterior insula (AI), inferior frontal junction (IFJ)). Comparing responses to the control stimulus with the deviant and standard enabled us to delineate the contributions of prediction error- or adaptation-related brain activation, respectively. We observed significant effects of adaptation in Heschl's gyrus, STG and ACC/SMA, while prediction error-related activity was observed in STG, IPL, AI and IFJ. Additional dynamic causal modeling confirmed the superiority of a hierarchical processing structure compared to a flat structure. Thus, we found that while prediction-error related processes increased with the hierarchical level of the brain area, adaptation declined. This suggests that the relative contribution of different mechanisms in deviance processing varies across the cortical hierarchy.
