EFFICIENCY IN TREATMENT OF CORNEAL ULCERS

Abstract

Purpose. To evaluate the efficacy of the treatment of corneal ulcers by intra-stromal injection of antibiotics in layers of cornea. Material and methods. The main group consisted of 23 patients who received besides the traditional treatment the additional method of the intra-stromal injection of cefuroxime in the cornea. The groups were statistically comparable in degree of severity. The efficacy of the treatment was assessed by the time period of epithelialization completion, by the terms of disappearance of purulent discharge, terms of attenuation of inflammatory response, the appearance of complications – panophthalmitis, the presence of corneal perforation. The follow-up period was 6 months. Results. The result of this study is an improvement of efficacy in the treatment of corneal ulcers: acceleration of the epithelialization time by 6.83±6.7% (p< 0.05), disappearance of inflammatory reactions in earlier periods, acceleration of the purification of corneal ulcers, improvement of visual acuity up to 0.1 and higher. Conclusion. The developed method is a sparing treatment of patients with ulcers of the cornea, which is characterized by a high efficiency and a decrease in the frequency of complications (panophthalmitis, perforation of the cornea) by 15.9±1.6% (p< 0.05). The use of this method in severe and extremely severe corneal ulcers enables to save the eye as an anatomical organ, to improve the possible prospects in a rehabilitation of the patients.

Keywords

• cornea
• ulcer
• intra-stromal injection
• cefuroxime