Structural assembly of the tailed bacteriophage ϕ29

Jingwei Xu; Dianhong Wang; Miao Gui; Ye Xiang

doi:10.1038/s41467-019-10272-3

Nature Communications (May 2019)

Structural assembly of the tailed bacteriophage ϕ29

Jingwei Xu,
Dianhong Wang,
Miao Gui,
Ye Xiang

Affiliations

Jingwei Xu: Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, Center for Infectious Disease Research, Department of Basic Medical Sciences, School of Medicine, Tsinghua University
Dianhong Wang: Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, Center for Infectious Disease Research, Department of Basic Medical Sciences, School of Medicine, Tsinghua University
Miao Gui: Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, Center for Infectious Disease Research, Department of Basic Medical Sciences, School of Medicine, Tsinghua University
Ye Xiang: Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center for Biological Structure, Center for Infectious Disease Research, Department of Basic Medical Sciences, School of Medicine, Tsinghua University

DOI: https://doi.org/10.1038/s41467-019-10272-3
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 16

Abstract

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Mature particles of bacteriophage ϕ29 consist of a 33-MDa complex formed by over 450 subunits, assembled into a head and a short tail. Here, Xu et al. report the near-atomic structures of the ϕ29 prohead, the mature virion and the genome-emptied virion, providing insights into DNA packaging and release.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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