International Journal of Nanomedicine (Jan 2022)

Therapeutic Applications of Antimicrobial Silver-Based Biomaterials in Dentistry

  • Wang Q,
  • Zhang Y,
  • Li Q,
  • Chen L,
  • Liu H,
  • Ding M,
  • Dong H,
  • Mou Y

Journal volume & issue
Vol. Volume 17
pp. 443 – 462

Abstract

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Qiyu Wang,1,* Yu Zhang,1,* Qiang Li,2,* Li Chen,1 Hui Liu,1 Meng Ding,2 Heng Dong,1 Yongbin Mou1 1Department of Oral Implantology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, People’s Republic of China; 2Central Laboratory, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yongbin Mou; Heng DongDepartment of Oral Implantology, Nanjing Stomatological Hospital, Medical School of Nanjing University, #30 Zhongyang Road, Nanjing, 210008, People’s Republic of China, Tel +86 25 83620236, Fax +86 25 83620202, Email [email protected]; [email protected]: Microbial infection accounts for many dental diseases and treatment failure. Therefore, the antibacterial properties of dental biomaterials are of great importance to the long-term results of treatment. Silver-based biomaterials (AgBMs) have been widely researched as antimicrobial materials with high efficiency and relatively low toxicity. AgBMs have a broad spectrum of antimicrobial properties, including penetration of microbial cell membranes, damage to genetic material, contact killing, and dysfunction of bacterial proteins and enzymes. In particular, advances in nanotechnology have improved the application value of AgBMs. Hence, in many subspecialties of dentistry, AgBMs have been researched and employed, such as caries arresting or prevention, root canal sterilization, periodontal plaque inhibition, additives in dentures, coating of implants and anti-inflammatory material in oral and maxillofacial surgery. This paper aims to provide an overview of the application approaches of AgBMs in dentistry and present better guidance for oral antimicrobial therapy via the development of AgBMs.Keywords: silver, antimicrobial, dentistry, oral biofilm formation, biomaterials, nanotechnology

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