Virology Journal (May 2010)

Human herpesvirus 6 infection impairs Toll-like receptor signaling

  • Ochi Toshiki,
  • Suemori Koichiro,
  • An Jun,
  • Fujiwara Hiroshi,
  • Tanimoto Kazushi,
  • Murakami Yuichi,
  • Hasegawa Hitoshi,
  • Yasukawa Masaki

DOI
https://doi.org/10.1186/1743-422X-7-91
Journal volume & issue
Vol. 7, no. 1
p. 91

Abstract

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Abstract Human herpesvirus 6 (HHV-6) has a tropism for immunocompetent cells, including T lymphocytes, monocytes/macrophages, and dendritic cells (DCs) suggesting that HHV-6 infection affects the immunosurveillance system. Toll-like receptor (TLR) system plays an important role in innate immunity against various pathogens. In the present study, we investigated the effect of HHV-6 infection on the expression and intracellular signaling of TLRs in DCs. Although expression levels of TLRs were not decreased or slightly elevated following HHV-6 infection, the amounts of cytokines produced following stimulation with ligands for TLRs appeared to be dramatically decreased in HHV-6-infected DCs as compared to mock-infected DCs. Similarly, phosphorylation levels of TAK-1, IκB kinase, and IκB-α following stimulation of HHV-6-infected DCs with lipopolysaccharide, which is the ligand for TLR4, appeared to be decreased. These data show that HHV-6 impairs intracellular signaling through TLRs indicating the novel mechanism of HHV-6-mediated immunomodulation.