In terms of the first and second laws of thermodynamics and economy, the thermo-economic analysis of a new ejector combined cooling and power cycle based on zeotropic working fluids was carried out. On this basis, the parameters of the cycle were analyzed. The effects of the five key parameters of composition ratio, evaporation temperature, condensing temperature, expansion ratio of expander, outlet temperature of steam generator on the thermal efficiency, exergy efficiency and capital cost rate were studied. Finally, taking the maximization of exergy efficiency and the minimization of cost rate as the objective function, Pareto optimal front was acquired by using NSGA-II. An exergy efficiency of 0.131 9 and capital cost rate of 1.94×10-5 $/s were selected as the best decision point by using TOPSIS decision method.