Recent Progress on Exosomes in the Diagnosis of Prostate Cancer

Abstract

Prostate cancer (Pca) is the second common cancer in men worldwide. Although prostate-specific antigen (PSA) screen can serve as a diagnostic marker in most of the patients with Pca, its diagnostic specificity is insufficient, and the false positive rate can result in unnecessary biopsy increasing pain and treatment costs in patients. Exosomes are source for mRNA, microRNA, non-encoded RNA, protein, and lipids. In recent years, exosome are used for assessment of tumors and serve as tumor markers for early diagnosis and disease prognosis. This article highlights the application of exosomes in connection with diagnosis, treatment and prognosis of Pca.

Keywords

• prostate cancer
• exosome
• tumor marker
• diagnosis