Zhongguo linchuang yanjiu (May 2023)
20230502 The mechanism of Nrf2 regulating oxidative stress in diabetes nephropathy http://zglcyj.ijournals.cn/zglcyj/ch/reader/create_pdf.aspx?file_no=20230502 10.13429/j.cnki.cjcr.2023.05.002 YIN Dapeng, GUO Zhixin Department of Endocrinology, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China Oxidative stress participates in the occurrence of diabetic nephropathy（DN）. Abnormal glucose metabolism will lead to the production of oxygen free radicals, damaging the intrinsic cells of the kidney, affecting the structure and function of renal tissue. Meanwhile, 〖JP2〗the high glucose-induced oxidative stress inhibits the expression of the antioxidant factor Nrf2, which activation has a protective effect on the kidney of diabetic mice, and can improve the kidney injury at the cellular level. However, the antioxidant mechanism of Nrf2 involved in DN remains unclear. This paper will introduce the role of Nrf2 in regulating oxidative stress at the cellular level to improve renal injury caused by high glucose. Oxidative stress, Nrf2, Diabetic nephropathy, Podocyte, Mesangial cells, Glomerular endothelial cells, Renal tubules, Ferroptosis 646 650 2022-12-08 2023-05-20 20230502 The mechanism of Nrf2 regulating oxidative stress in diabetes nephropathy http://zglcyj.ijournals.cn/zglcyj/ch/reader/create_pdf.aspx?file_no=20230502 10.13429/j.cnki.cjcr.2023.05.002 YIN Dapeng, GUO Zhixin Department of Endocrinology, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China Oxidative stress participates in the occurrence of diabetic nephropathy（DN）. Abnormal glucose metabolism will lead to the production of oxygen free radicals, damaging the intrinsic cells of the kidney, affecting the structure and function of renal tissue. Meanwhile, 〖JP2〗the high glucose-induced oxidative stress inhibits the expression of the antioxidant factor Nrf2, which activation has a protective effect on the kidney of diabetic mice, and can improve the kidney injury at the cellular level. However, the antioxidant mechanism of Nrf2 involved in DN remains unclear. This paper will introduce the role of Nrf2 in regulating oxidative stress at the cellular level to improve renal injury caused by high glucose. Oxidative stress, Nrf2, Diabetic nephropathy, Podocyte, Mesangial cells, Glomerular endothelial cells, Renal tubules, Ferroptosis 646 650 2022-12-08 2023-05-20 The mechanism of Nrf2 regulating oxidative stress in diabetes nephropathy
Abstract
Oxidative stress participates in the occurrence of diabetic nephropathy（DN）. Abnormal glucose metabolism will lead to the production of oxygen free radicals, damaging the intrinsic cells of the kidney, affecting the structure and function of renal tissue. Meanwhile, the high glucose-induced oxidative stress inhibits the expression of the antioxidant factor Nrf2, which activation has a protective effect on the kidney of diabetic mice, and can improve the kidney injury at the cellular level. However, the antioxidant mechanism of Nrf2 involved in DN remains unclear. This paper will introduce the role of Nrf2 in regulating oxidative stress at the cellular level to improve renal injury caused by high glucose.
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