Nature Communications (Feb 2022)
TNF antagonist sensitizes synovial fibroblasts to ferroptotic cell death in collagen-induced arthritis mouse models
- Jiao Wu,
- Zhuan Feng,
- Liang Chen,
- Yong Li,
- Huijie Bian,
- Jiejie Geng,
- Zhao-Hui Zheng,
- Xianghui Fu,
- Zhuo Pei,
- Yifei Qin,
- Liu Yang,
- Yilin Zhao,
- Ke Wang,
- Ruo Chen,
- Qian He,
- Gang Nan,
- Xuejun Jiang,
- Zhi-Nan Chen,
- Ping Zhu
Affiliations
- Jiao Wu
- Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University
- Zhuan Feng
- National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University
- Liang Chen
- School of Medicine, Shanghai University
- Yong Li
- Xijing 986 Hospital Department, Fourth Military Medical University
- Huijie Bian
- National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University
- Jiejie Geng
- National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University
- Zhao-Hui Zheng
- Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University
- Xianghui Fu
- Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University
- Zhuo Pei
- National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University
- Yifei Qin
- National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University
- Liu Yang
- National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University
- Yilin Zhao
- Department of Oncology, Xijing Hospital, Fourth Military Medical University
- Ke Wang
- National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University
- Ruo Chen
- National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University
- Qian He
- National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University
- Gang Nan
- National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University
- Xuejun Jiang
- Cell Biology Program, Memorial Sloan-Kettering Cancer Center
- Zhi-Nan Chen
- National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University
- Ping Zhu
- Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University
- DOI
- https://doi.org/10.1038/s41467-021-27948-4
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
Expansion of synovial fibroblast is associated with rheumatoid arthritis (RA) progression, but how this expansion is regulated is still not clear. Here the authors use a mouse RA model, single cell RNA sequencing and in vitro analyses to show that inducing ferroptosis and suppressing TNF signaling reduce fibroblast numbers and ameliorate experimental arthritis.
