Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development

Susanne Laukoter; Robert Beattie; Florian M. Pauler; Nicole Amberg; Keiichi I. Nakayama; Simon Hippenmeyer

doi:10.1038/s41467-019-14077-2

Nature Communications (Jan 2020)

Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development

Susanne Laukoter,
Robert Beattie,
Florian M. Pauler,
Nicole Amberg,
Keiichi I. Nakayama,
Simon Hippenmeyer

Affiliations

Susanne Laukoter: Institute of Science and Technology Austria
Robert Beattie: Institute of Science and Technology Austria
Florian M. Pauler: Institute of Science and Technology Austria
Nicole Amberg: Institute of Science and Technology Austria
Keiichi I. Nakayama: Department of Molecular and Cellular Biology, Kyushu University
Simon Hippenmeyer: Institute of Science and Technology Austria

DOI: https://doi.org/10.1038/s41467-019-14077-2
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 14

Abstract

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How the imprinted Cdkn1c locus regulates corticogenesis is unclear. Here, the authors dissect the level of cell-autonomy of imprinted Cdkn1c gene function in mouse corticogenesis and identify this as regulating radial glial progenitor cell and projection neuron survival.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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