Kitamura Electrophilic Fluorination Using HF as a Source of Fluorine
Jianlin Han,
Greg Butler,
Hiroki Moriwaki,
Hiroyuki Konno,
Vadim A. Soloshonok,
Tsugio Kitamura
Affiliations
Jianlin Han
Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, Jiangsu, China
Greg Butler
Oakwood Chemical, Inc. 730 Columbia Hwy. N, Estill, SC 29918, USA
Hiroki Moriwaki
Hamari Chemical Ltd., 1-4-29 Kunijima, Higashi-Yodogawa-ku, Osaka 533-0024, Japan
Hiroyuki Konno
Department of Biological Engineering, Graduate School of Science and Engineering, Yamagata University, Yonezawa, Yamagata 992-8510, Japan
Vadim A. Soloshonok
Department of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel Lardizábal 3, 20018 San Sebastián, Spain
Tsugio Kitamura
Department of Chemistry and Applied Chemistry, Saga University, 1 Honjo-machi, Saga 840-8502, Japan
This review article focused on the innovative procedure for electrophilic fluorination using HF and in situ generation of the required electrophilic species derived from hypervalent iodine compounds. The areas of synthetic application of this approach include fluorination of 1,3-dicarbonyl compounds, aryl-alkyl ketones, styrene derivatives, α,β-unsaturated ketones and alcohols, homoallyl amine and homoallyl alcohol derivatives, 3-butenoic acids and alkynes.
