An elastic element in the protocadherin-15 tip link of the inner ear

Raul Araya-Secchi; Brandon L. Neel; Marcos Sotomayor

doi:10.1038/ncomms13458

Nature Communications (Nov 2016)

An elastic element in the protocadherin-15 tip link of the inner ear

Raul Araya-Secchi,
Brandon L. Neel,
Marcos Sotomayor

Affiliations

Raul Araya-Secchi: Department of Chemistry and Biochemistry, The Ohio State University
Brandon L. Neel: Department of Chemistry and Biochemistry, The Ohio State University
Marcos Sotomayor: Department of Chemistry and Biochemistry, The Ohio State University

DOI: https://doi.org/10.1038/ncomms13458
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 14

Abstract

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Tip-link filaments convey force to activate hair cells, important sensory receptors. Here the authors solve a partial structure of human protocadherin-15, a tip-link component with an unusual Ca2+–free linker that bends and is predicted to confer flexibility to this filament during inner-ear mechanotransduction.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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