Integron in Gram negative bacteria: Classes and fitness cost

Abstract

Bacteria intrinsically harbor methods of gene exchange that are distinct from those in eukaryotes, but subject to natural selection laws. Dissemination of antimicrobial resistance is one of the major consequences of gene exchange ability. Bacterial genomes have the ability to undergo evolutionary changes within specified time frame resulting on an exceptional diversity, especially, under strong selection pressure. One of the most important elements of antimicrobial resistance are integrons which serve as a platform for gene cassettes integration and expression.

Keywords

• integron
• integrase
• fitness cost
• gene cassette