Nature Communications (Jan 2021)

LEAFY is a pioneer transcription factor and licenses cell reprogramming to floral fate

  • Run Jin,
  • Samantha Klasfeld,
  • Yang Zhu,
  • Meilin Fernandez Garcia,
  • Jun Xiao,
  • Soon-Ki Han,
  • Adam Konkol,
  • Doris Wagner

DOI
https://doi.org/10.1038/s41467-020-20883-w
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

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Pioneer transcription factors access their DNA binding motifs in closed chromatin and often act in cell fate reprogramming. Here, Jin et al. present biochemical evidence for a pioneer factor in plants and show that LFY promotes floral cell fate and locally unlocks chromatin by displacing histone H1 and recruiting SWI/SNF chromatin remodelers.