Case Report: Low Dose of Valsartan/Sacubitril Leads to Successful Reversal of Acute Heart Failure in Chemotherapy-Induced Cardiomyopathy

Shih-Hsing Lo; Yi-Ching Liu; Zen-Kong Dai; Zen-Kong Dai; I-Chen Chen; I-Chen Chen; Yen-Hsien Wu; Jong-Hau Hsu; Jong-Hau Hsu

doi:10.3389/fped.2021.639551

Frontiers in Pediatrics (Feb 2021)

Case Report: Low Dose of Valsartan/Sacubitril Leads to Successful Reversal of Acute Heart Failure in Chemotherapy-Induced Cardiomyopathy

Shih-Hsing Lo,
Yi-Ching Liu,
Zen-Kong Dai,
Zen-Kong Dai,
I-Chen Chen,
I-Chen Chen,
Yen-Hsien Wu,
Jong-Hau Hsu,
Jong-Hau Hsu

Affiliations

Shih-Hsing Lo: Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
Yi-Ching Liu: Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
Zen-Kong Dai: Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
Zen-Kong Dai: Department of Pediatrics, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
I-Chen Chen: Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
I-Chen Chen: Department of Pediatrics, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
Yen-Hsien Wu: Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
Jong-Hau Hsu: Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
Jong-Hau Hsu: Department of Pediatrics, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

DOI: https://doi.org/10.3389/fped.2021.639551
Journal volume & issue: Vol. 9

Abstract

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Valsartan/sacubitril is a new agent approved for the treatment of chronic heart failure in adults, with a combination of angiotensin receptor inhibitor and neprilysin inhibitor. However, the benefit of valsartan/sacubitril in pediatric patients is unknown. We herein report its clinical benefit in a case of acute decompensated heart failure in chemotherapy-induced cardiomyopathy. This case suggests that in children with acute heart failure refractory to conventional medications, low dose of sacubitril/valsartan may be an effective therapy.

Published in Frontiers in Pediatrics

ISSN: 2296-2360 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Pediatrics
Website: http://journal.frontiersin.org/journal/pediatrics

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