The Effect of Indium on Intestinal Absorption of Iron Using Everted Gut Sac Method

Abstract

Iron is an essential metal which involves in more cell activities in the form of enzymes and / or other metaloproteins . Indium is one of the toxic elements that may be interfered with iron metabolism . Using this element has increased recently by different industry. Therefore the aim of this investigation was to study interfer of indium on first phase of iron metabolism (absorption intestinal ) by everted gut sac (E.G.S) . Preliminary results showed that the optimum concentration of iron and indium for best intestinal absorption were 102 and 70 mg/L , respectively . Addition of glucose to incubation media caused increase in iron and / or indium absorption and reduction was seen where ouabain was added to the media , suggest a probable active transport of the element across of the intestinal mucosal cell . Iron absorption was reduced almost by 28% when indium was presented in incubation media . Results obtained from this study indicated that indium might be able to interfer with iron metabolism , at intestinal absorption .

Keywords

• everted gut sac
• indium
• iron
• rats