Renal pathology features in arterial hypertension patients with and without metabolic syndrome

Abstract

The study included 303 patients (110 men, 193 women) with Stage I-III arterial hypertension (AH), aged 25–70 years (mean age 52±18 years). All participants were divided into two groups, comparable by age and sex distribution: Group A (n=151) – with metabolic syndrome (MS), and Group B (n=152) – without MS. Each group was divided into three subgroups, according to AH stage (I, II, III). All patients underwent clinical examination, 24-hout blood pressure (BP) monitoring, renal function assessment (glomerular filtration rate, GFR, and microalbuminuria, MAU). MS criteria were specified according to the recommendations by International Diabetic Foundation (IDF, 2005). The data obtained demonstrated that MAU was an early marker of renal pathology in AH, especially when combined with MS. MAU level was significantly higher in individuals with AH and MS, comparing to hypertensive participants without metabolic disturbances. Group A demonstrated significant correlations between MAU, lipid and carbohydrate metabolism parameters and circadian BP profile. GFR correlation with MS was substantially weaker.

Keywords

• arterial hypertension
• metabolic syndrome
• glomerular filtration rate
• microalbuminuria