Metal-free alcohol-directed regioselective heteroarylation of remote unactivated C(sp3)–H bonds

Xinxin Wu; Hong Zhang; Nana Tang; Zhen Wu; Dongping Wang; Meishan Ji; Yan Xu; Min Wang; Chen Zhu

doi:10.1038/s41467-018-05522-9

Nature Communications (Aug 2018)

Metal-free alcohol-directed regioselective heteroarylation of remote unactivated C(sp3)–H bonds

Xinxin Wu,
Hong Zhang,
Nana Tang,
Zhen Wu,
Dongping Wang,
Meishan Ji,
Yan Xu,
Min Wang,
Chen Zhu

Affiliations

Xinxin Wu: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University
Hong Zhang: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University
Nana Tang: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University
Zhen Wu: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University
Dongping Wang: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University
Meishan Ji: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University
Yan Xu: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University
Min Wang: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University
Chen Zhu: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University

DOI: https://doi.org/10.1038/s41467-018-05522-9
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 8

Abstract

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Direct remote C–H functionalization of aliphatic alcohols via alkoxy radicals is largely unexplored. Here, the authors report the C(sp3)-heteroaryl bond formation in aliphatic alcohols mediated by alkoxy radicals formed with a hypervalent iodine reagent.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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