International Journal of Women's Health (Nov 2023)
Relationship Between the Ovarian Cyst and Depression: A Two-Sample Mendelian Randomization Study
Abstract
Jiajia Wen,1 Wamei Zhou,2 Yin Lin3 1Department of Psychiatry III, Hainan an Ning Hospital, Haikou, People’s Republic of China; 2Department of Neurology, Hainan an Ning Hospital, Haikou, People’s Republic of China; 3Department of Psychiatry, Hainan an Ning Hospital, Haikou, People’s Republic of ChinaCorrespondence: Yin Lin, Department of Psychiatry, Hainan an Ning Hospital, No. 10, Nanhai Avenue East, Haikou, Hainan, 570100, People’s Republic of China, Tel +8613876245292, Email [email protected]: Explore the causal relationship between the ovarian cyst and depression using a two-sample Mendelian randomization approach (MR).Methods: Based on data pooled from genome-wide association studies, genetic variants of the ovarian cyst and depression were selected as instrumental variables, as well as the Mendelian randomization analysis was conducted using inverse variance weighted (IVW) as the main analysis method and MR-Egger regression analysis, MR-PRESSO and other sensitivity analysis methods as supplements.Results: The IVW analysis showed a direct causal association between ovarian cysts and depression (OR=1.040; 95% CI: 1.003, 1.078; p=0.031). Meantime, there was a causal effect of genetically predicted depression on ovarian cysts (OR=1.327.; 95% CI: 1.197, 1.470; p< 0.001). Sensitivity analyses such as MR-Egger regression analysis and MR-PRESSO indicated that the IVW results were robust and reliable.Conclusion: This study suggested since ovarian cysts and female depression are mutually causal, the comorbidity of ovarian cysts and depression in women should be actively attended to and given appropriate prevention and treatment besides the diagnosis and treatment of depression or ovarian cysts.Keywords: Mendelian randomization, depression, ovarian cyst, genetic variation
