Natural polyphenols in drug delivery systems: Current status and future challenges
Hui Wang,
Changping Wang,
Yuan Zou,
Jingjing Hu,
Yiwen Li,
Yiyun Cheng
Affiliations
Hui Wang
South China Advanced Institute for Soft Matter Science and Technology, School of Molecular Science and Engineering, South China University of Technology, Guangzhou 510640, China
Changping Wang
South China Advanced Institute for Soft Matter Science and Technology, School of Molecular Science and Engineering, South China University of Technology, Guangzhou 510640, China
Yuan Zou
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China
Jingjing Hu
Shanghai Key Laboratory of Regulatory Biology, East China Normal University, Shanghai 200241, China
Yiwen Li
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China; Corresponding author.
Yiyun Cheng
South China Advanced Institute for Soft Matter Science and Technology, School of Molecular Science and Engineering, South China University of Technology, Guangzhou 510640, China; Shanghai Key Laboratory of Regulatory Biology, East China Normal University, Shanghai 200241, China; Corresponding author at: South China Advanced Institute for Soft Matter Science and Technology, School of Molecular Science and Engineering, South China University of Technology, Guangzhou 510640, China.
Natural polyphenols have attracted great interests in medicine, food and cosmetics due to their versatile functions such as antioxidant, anticancer and antibacterial. The polyphenolic structures (i.e. catechol, and pyrogallol) in natural polyphenols are responsible for strong noncovalent interactions via multiple hydrogen bonding and hydrophobic interactions, and dynamic covalent complexation with boronate groups and multiple metal ions. In this review, we focused on the preparation and applications of natural polyphenol-based coating films, nanoparticles, nanocapsules, and hydrogels emerged from their chemical and functional signatures. The beneficial role and mechanism of natural polyphenols in facilitating the delivery of proteins, nucleic acids and conventional drug molecules were reviewed. Finally, the challenges of natural polyphenol-based delivery systems and perspectives in rational design of next generation natural polyphenol biomaterials will be discussed.
