Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing

Hamza Atcha; Amit Jairaman; Jesse R. Holt; Vijaykumar S. Meli; Raji R. Nagalla; Praveen Krishna Veerasubramanian; Kyle T. Brumm; Huy E. Lim; Shivashankar Othy; Michael D. Cahalan; Medha M. Pathak; Wendy F. Liu

doi:10.1038/s41467-021-23482-5

Nature Communications (May 2021)

Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing

Hamza Atcha,
Amit Jairaman,
Jesse R. Holt,
Vijaykumar S. Meli,
Raji R. Nagalla,
Praveen Krishna Veerasubramanian,
Kyle T. Brumm,
Huy E. Lim,
Shivashankar Othy,
Michael D. Cahalan,
Medha M. Pathak,
Wendy F. Liu

Affiliations

Hamza Atcha: Department of Biomedical Engineering, University of California Irvine
Amit Jairaman: Department of Physiology and Biophysics, University of California Irvine
Jesse R. Holt: Department of Physiology and Biophysics, University of California Irvine
Vijaykumar S. Meli: Department of Biomedical Engineering, University of California Irvine
Raji R. Nagalla: Department of Biomedical Engineering, University of California Irvine
Praveen Krishna Veerasubramanian: Department of Biomedical Engineering, University of California Irvine
Kyle T. Brumm: Department of Biomedical Engineering, University of California Irvine
Huy E. Lim: Department of Biomedical Engineering, University of California Irvine
Shivashankar Othy: Department of Physiology and Biophysics, University of California Irvine
Michael D. Cahalan: Department of Physiology and Biophysics, University of California Irvine
Medha M. Pathak: Department of Biomedical Engineering, University of California Irvine
Wendy F. Liu: Department of Biomedical Engineering, University of California Irvine

DOI: https://doi.org/10.1038/s41467-021-23482-5
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 14

Abstract

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Macrophages perform diverse functions during immune responses, but the molecular mechanisms by which physical properties of the tissue regulate macrophage behavior remain unknown. Here the authors find that Piezo1 is a mechanosensor of stiffness, and that its activity modulates macrophage polarization responses.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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