Journal of Mazandaran University of Medical Sciences (Jul 2023)
Healing Effect of Trigonella foenum-graceum L. and Convolvulus arvensis L. Ointments on Rat Model of Burn Wounds
Abstract
Background and purpose: Wound is a complication with high prevalence that negatively affects many people. The aim of this study was to evaluate the effects of Trigonella foenum-graceum L. and Convolvulus arvensis L. extracts on induced burn wounds in male Wistar rats. Materials and methods: Burn wounds were induced by hot plates burns under anesthesia. Twenty five rats were divided into five groups: normal saline, Eucerin, silver sulfadiazine, treatment groups treated with ointments containing 2.5% of Trigonella foenum-graceum L. or Convolvulus arvensis L. extracts. The wound area was measured at days 7, 14, 21, and 28, and 28 days after wound formation. Histopathological evaluation of the recovered tissue samples was done. Total flavonoids of the two extracts were determined. Microscopic analysis of wound healing was carried out and pathologic data were statistically evaluated. Results: In this study, wound size significantly decreased in rats treated with Convolvulus arvensis L. compared to Eucerin and normal saline groups. Furthermore, Trigonella foenum-graceum L. showed better efficacy than Eucerin. Pathological examination showed the highest improvements in the Trigonella foenum-graceum L. group and then in the Convolvulus arvensis L. group. Conclusion: Topical administration of Trigonella foenum-graceum L. and the Convolvulus arvensis L, with rich flavonoid contents can be beneficial in treatment of burn wound healing.
