Nature Communications (Sep 2021)

Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer

  • Jianhuang Lin,
  • Heng Liu,
  • Takeshi Fukumoto,
  • Joseph Zundell,
  • Qingqing Yan,
  • Chih-Hang Anthony Tang,
  • Shuai Wu,
  • Wei Zhou,
  • Dajiang Guo,
  • Sergey Karakashev,
  • Chih-Chi Andrew Hu,
  • Kavitha Sarma,
  • Andrew V. Kossenkov,
  • Rugang Zhang

DOI
https://doi.org/10.1038/s41467-021-25684-3
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

Read online

The unfolded protein response (UPR) promotes cell survival in cancers with hyperactive ER stress response. Here the authors show that CARM1, an arginine methyltransferase, controls the IRE1α/XBP1 pathway of the UPR and the inhibition of this pathway can inhibit growth in CARM1 expressing ovarian cancers.