CHIMIA (May 2007)

Peptides as Asymmetric Catalysts for Aldol Reactions

  • Helma Wennemers

DOI
https://doi.org/10.2533/chimia.2007.276
Journal volume & issue
Vol. 61, no. 5

Abstract

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The article summarizes our research devoted to the development of peptidic catalysts for aldol reactions. Using the combinatorial method of 'catalyst–substrate coimmobilization' the peptides H-Pro-Pro-Asp-NH2 and H-Pro-D-Ala-D-Asp-NH2 were identified as highly active and selective catalysts for direct aldol reactions. The results demonstrate that the higher complexity of peptides in comparison to rigid small organocatalysts can be a good trade-off for higher activity.

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