Mechanisms of bronchial asthma control disturbance in using 2-agonists

Abstract

Despite exclusively high clinical efficacy of 2-agonists in bronchospasm, their regular using is associated with increased level of bronchial asthma control and the development of severe and life-threatening states which in turn is associated with increasing bronchial hyper-reactivity, development of partial tolerance, increased allergic load and masking of the disease aggravation. Deve- lopment of tolerance to 2-agonists and increasing sensibility of bronchi to bronchoconstrictive stimuli are based on specific mecha-nisms including desensitization of 2-adrenoreceptor, increasing expression of C phospholipase and mechanisms associated with gene AP variants which are not studied enough.

Keywords

• β₂-адренорецептор
• бронхиальная астма
• β₂-агонисты
• контроль
• десенситизация