miR-1199-5p and Zeb1 function in a double-negative feedback loop potentially coordinating EMT and tumour metastasis

Maren Diepenbruck; Stefanie Tiede; Meera Saxena; Robert Ivanek; Ravi Kiran Reddy Kalathur; Fabiana Lüönd; Nathalie Meyer-Schaller; Gerhard Christofori

doi:10.1038/s41467-017-01197-w

Nature Communications (Oct 2017)

miR-1199-5p and Zeb1 function in a double-negative feedback loop potentially coordinating EMT and tumour metastasis

Maren Diepenbruck,
Stefanie Tiede,
Meera Saxena,
Robert Ivanek,
Ravi Kiran Reddy Kalathur,
Fabiana Lüönd,
Nathalie Meyer-Schaller,
Gerhard Christofori

Affiliations

Maren Diepenbruck: Department of Biomedicine, University of Basel
Stefanie Tiede: Department of Biomedicine, University of Basel
Meera Saxena: Department of Biomedicine, University of Basel
Robert Ivanek: Department of Biomedicine, University of Basel
Ravi Kiran Reddy Kalathur: Department of Biomedicine, University of Basel
Fabiana Lüönd: Department of Biomedicine, University of Basel
Nathalie Meyer-Schaller: Department of Biomedicine, University of Basel
Gerhard Christofori: Department of Biomedicine, University of Basel

DOI: https://doi.org/10.1038/s41467-017-01197-w
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

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miRNAs have been involved in tumour development and progression. Here the authors uncover a double feedback loop between miR-1199-5p and the Zeb1, potentially coordinating a protein involved in epithelial mesenchymal transition and tumour metastasis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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