Central nervous system post-transplant lymphoproliferative disorder after allogeneic hematopoietic stem cell transplantation: The Nagasaki transplant group experience

Hikaru Sakamoto; Hidehiro Itonaga; Jun Taguchi; Takeharu Kato; Yasushi Sawayama; Tomayoshi Hayashi; Shiro Baba; Masako Moriuchi; Koichi Ohshima; Shinichiro Yoshida; Yukiyoshi Moriuchi; Yasushi Miyazaki

Leukemia Research Reports (Jan 2019)

Central nervous system post-transplant lymphoproliferative disorder after allogeneic hematopoietic stem cell transplantation: The Nagasaki transplant group experience

Hikaru Sakamoto,
Hidehiro Itonaga,
Jun Taguchi,
Takeharu Kato,
Yasushi Sawayama,
Tomayoshi Hayashi,
Shiro Baba,
Masako Moriuchi,
Koichi Ohshima,
Shinichiro Yoshida,
Yukiyoshi Moriuchi,
Yasushi Miyazaki

Affiliations

Hikaru Sakamoto: Department of Hematology, Nagasaki University Hospital, Nagasaki, Japan
Hidehiro Itonaga: Department of Hematology, Nagasaki University Hospital, Nagasaki, Japan; Correspondence to: Department of Hematology, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
Jun Taguchi: Department of Hematology, Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki, Japan
Takeharu Kato: Department of Hematology, National Hospital Organization Nagasaki Medical Center, Omura, Japan
Yasushi Sawayama: Department of Hematology, Nagasaki University Hospital, Nagasaki, Japan
Tomayoshi Hayashi: Department of Pathology, Nagasaki Prefecture Shimabara Hospital, Shimabara, Japan
Shiro Baba: Department of Neurosurgery, Nagasaki University Hospital, Nagasaki, Japan
Masako Moriuchi: Department of Pediatrics, Nagasaki University Graduate School of Biomedical Sciences, Japan
Koichi Ohshima: Department of Pathology, School of Medicine, Kurume University, Kurume, Japan
Shinichiro Yoshida: Department of Hematology, National Hospital Organization Nagasaki Medical Center, Omura, Japan
Yukiyoshi Moriuchi: Department of Hematology, Sasebo City General Hospital, Sasebo, Japan
Yasushi Miyazaki: Department of Hematology, Nagasaki University Hospital, Nagasaki, Japan; Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan

Journal volume & issue: Vol. 11
pp. 27 – 30

Abstract

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A 17-year-old male received allogeneic transplantation for acute lymphoblastic leukemia, and presented with generalized seizures due to a solitary brain lesion with massive necrosis on day +621. Epstein–Barr virus (EBV) DNA copies were below the cut-off value in plasma. Stereotactic biopsy of the cerebral lesion confirmed the diagnosis of post-transplant lymphoproliferative disorder (PTLD) with large atypical cells positive for CD20 and EBER. In order to diagnose primary central nervous system PTLD, the biopsy should be applied as early as possible when brain lesion with necrosis develops in post-transplant patients regardless of EBV-DNA in plasma. Keywords: Post-transplant lymphoproliferative disorder, Central nervous system, Epstein–Barr virus, Allogeneic hematopoietic stem cell transplantation

Published in Leukemia Research Reports

ISSN: 2213-0489 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: http://www.journals.elsevier.com/leukemia-research-reports/

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