Seroprevalence of AIH-related autoantibodies in patients with acute hepatitis E viral infection: a prospective case–control study in China

Jian Wu; Naizhou Guo; Lifei Zhu; Xueyan Zhang; Cunquan Xiong; Jun Liu; Yanping Xu; Jun Fan; Jiong Yu; Qiaoling Pan; Jinfeng Yang; Hanying Liang; Xiuyuan Jin; Sunyi Ye; Wei Wang; Chengyuan Liu; Jinrong Zhang; Gongqi Li; Bin Jiang; Hongcui Cao; Lanjuan Li

doi:10.1080/22221751.2020.1722759

Emerging Microbes and Infections (Jan 2020)

Seroprevalence of AIH-related autoantibodies in patients with acute hepatitis E viral infection: a prospective case–control study in China

Jian Wu,
Naizhou Guo,
Lifei Zhu,
Xueyan Zhang,
Cunquan Xiong,
Jun Liu,
Yanping Xu,
Jun Fan,
Jiong Yu,
Qiaoling Pan,
Jinfeng Yang,
Hanying Liang,
Xiuyuan Jin,
Sunyi Ye,
Wei Wang,
Chengyuan Liu,
Jinrong Zhang,
Gongqi Li,
Bin Jiang,
Hongcui Cao,
Lanjuan Li

Affiliations

Jian Wu: State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China
Naizhou Guo: Department of Laboratory Medicine, The First People’s Hospital of Yancheng City, Yancheng, People’s Republic of China
Lifei Zhu: State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China
Xueyan Zhang: Department of Public Health, Jiangsu Vocational College of Medicine, Yancheng, People’s Republic of China
Cunquan Xiong: Department of Public Health, Jiangsu Vocational College of Medicine, Yancheng, People’s Republic of China
Jun Liu: Department of Laboratory Medicine, The Fifth People’s Hospital of Wuxi, Affiliated to Jiangnan University, Wuxi, People’s Republic of China
Yanping Xu: State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China
Jun Fan: State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China
Jiong Yu: State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China
Qiaoling Pan: State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China
Jinfeng Yang: State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China
Hanying Liang: State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China
Xiuyuan Jin: State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China
Sunyi Ye: State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China
Wei Wang: Department of Laboratory Medicine, The First People’s Hospital of Yancheng City, Yancheng, People’s Republic of China
Chengyuan Liu: Department of Laboratory Medicine, The First People’s Hospital of Yancheng City, Yancheng, People’s Republic of China
Jinrong Zhang: Department of Laboratory Medicine, The People’s Hospital of Dafeng City, Yancheng, People’s Republic of China
Gongqi Li: Department of Clinical Laboratory, Linyi Traditional Hospital, Linyi, People’s Republic of China
Bin Jiang: Department of Laboratory Medicine, The Central Blood Station of Yancheng City, Yancheng, People’s Republic of China
Hongcui Cao: State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China
Lanjuan Li: State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China

DOI: https://doi.org/10.1080/22221751.2020.1722759
Journal volume & issue: Vol. 9, no. 1
pp. 332 – 340

Abstract

Read online

ABSTRACTThe seroprevalenc of autoimmune hepatitis (AIH)-related antibodies in patients, particularly Asians, with acute hepatitis E (AHE) is unclear. In this study, we investigated whether acute hepatitis E virus (HEV) infection is associated with the seroprevalence of AIH-related autoantibodies and assessed their impact on the disease characteristics. AIH-related autoantibodies were detected by indirect immunofluorescence in 198 AHE patients and 50 type 1 AIH patients. The positivity rates of against nuclear antigen (ANA) and smooth muscles antibody (SMA) in AHE patients were 37.4% and 22.7%, and the total positivity rate was 50%. Compared to those in AIH patients, the positivity rates of ANA-H and SMA-AA were significantly lower (35.1% vs. 82.1% and 4.4% vs. 88.4%). Female gender and the ALT level, but not immunosuppressive or antiviral drugs, were independently predictive of the presence of AIH-related autoantibodies in AHE patients. Fifty-two patients positive for AIH-related autoantibodies were followed up for 12 months. During this period, 33 of them became negative and 19 remained positive, albeit with significantly decreased titres. In conclusions, the seroprevalence of AIH-related autoantibodies in AHE patients was elevated, particularly in females, but their subspecificities and titres differed from those of type 1 AIH. Acute HEV infection may be related to AIH.Abbreviations: AIH: autoimmune hepatitis; AHE: acute hepatitis E; ANA: against nuclear antigen; SMA: smooth muscles antibody; ANA-H: ANA with homogeneous pattern; SMA-AA: SMA with anti-actin pattern; Anti-LKM1: anti- liver-kidney microsomes-1 antibody; ANCA: anti-neutrophil cytoplasmic antibody; AMA: anti-mitochondrial antibody; Anti-SLA: anti-soluble liver antigen; Anti-LC1: anti-liver cytoplasmic type 1 antibody; pANCA: perinuclear antineutrophil cytoplasmic antibody

Published in Emerging Microbes and Infections

ISSN: 2222-1751 (Online)
Publisher: Taylor & Francis Group
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases; Science: Microbiology
Website: https://www.tandfonline.com/journals/temi

About the journal

Abstract

Keywords