ABCB1 gene polymorphisms is not associated with drug-resistant epilepsy in Romanian children

Abstract

Background: P-glycoprotein (P-gp), a drug efflux transporter, encoded by the gene MDR1 ABCB1 multidrug resistant, reduces the penetration through the brain by the AEDs. Overexpression of Pgp in blood-brain barrier in epileptic patients play an important rol in pharmacoresistance. The aim of this study was to evaluate a possible association between C1236T and G2677T ABCB1 gene polymorphisms and drug-resistant epilepsy in Romanian children.

Keywords

• c1236t
• g2677t
• abcb1 gene
• epilepsy
• children
• c1236t
• g2677t
• gena abcb1
• epilepsie
• copii