Acta Neuropathologica Communications (Feb 2024)
The cycad genotoxin methylazoxymethanol, linked to Guam ALS/PDC, induces transcriptional mutagenesis
- Bert M. Verheijen,
- Claire Chung,
- Ben Thompson,
- Hyunjin Kim,
- Asa Nakahara,
- Jasper J. Anink,
- James D. Mills,
- NYGC ALS Consortium,
- Jeong H. Lee,
- Eleonora Aronica,
- Kiyomitsu Oyanagi,
- Akiyoshi Kakita,
- Jean-Francois Gout,
- Marc Vermulst
Affiliations
- Bert M. Verheijen
- School of Gerontology, University of Southern California
- Claire Chung
- School of Gerontology, University of Southern California
- Ben Thompson
- Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST)
- Hyunjin Kim
- Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine
- Asa Nakahara
- Department of Pathology, Brain Research Institute, Niigata University
- Jasper J. Anink
- Department of Neuropathology, Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience
- James D. Mills
- Department of Neuropathology, Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience
- NYGC ALS Consortium
- Jeong H. Lee
- Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST)
- Eleonora Aronica
- Department of Neuropathology, Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience
- Kiyomitsu Oyanagi
- Division of Neuropathology, Department of Brain Disease Research, Shinshu University School of Medicine
- Akiyoshi Kakita
- Department of Pathology, Brain Research Institute, Niigata University
- Jean-Francois Gout
- Department of Biological Sciences, Mississippi State University
- Marc Vermulst
- School of Gerontology, University of Southern California
- DOI
- https://doi.org/10.1186/s40478-024-01725-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 5
Abstract
No abstracts available.Keywords
- Guam amyotrophic lateral sclerosis/parkinsonism–dementia complex
- Environmental toxin
- DNA damage
- O6-mG
- Transcriptional mutagenesis