Nature Communications (Jan 2023)
Human mitochondria require mtRF1 for translation termination at non-canonical stop codons
Abstract
The mammalian mitochondrial genome contains two noncanonical stop codons, AGA and AGG. Here, the authors show that mtRF1, a mitochondrial protein of unknown function, triggers translation termination at AGA or AGG, placing mtRF1 among mitochondrial translation factors.