Association between sleep duration and serum neurofilament light chain levels among adults in the United States
Jiaxing Liang,
Tengchi Ma,
Youlei Li,
Ruixin Sun,
Shuaishuai Zhao,
Yuzhe Shen,
Hui Gao,
Yunhang Jing,
Xinyue Bai,
Mengze He,
Qingyan Wang,
Huilin Xi,
Rui Shi,
Yanling Yang
Affiliations
Jiaxing Liang
Medical School of Yan'an University, Yan'an, China; Yan'an Key Laboratory of Neuroscience, Yan'an, China
Tengchi Ma
Medical School of Yan'an University, Yan'an, China; The First Affiliated Hospital of Xi’an Jiao tong University Yulin Hospital, Yulin, China
Youlei Li
Medical School of Yan'an University, Yan'an, China; Yan'an Key Laboratory of Neuroscience, Yan'an, China
Ruixin Sun
Medical School of Yan'an University, Yan'an, China; Yan'an Key Laboratory of Neuroscience, Yan'an, China; Medical School of Xi'an International University, Xi'an, China
Shuaishuai Zhao
Medical School of Yan'an University, Yan'an, China; Yan'an Key Laboratory of Neuroscience, Yan'an, China
Yuzhe Shen
Medical School of Yan'an University, Yan'an, China; Yan'an Key Laboratory of Neuroscience, Yan'an, China
Hui Gao
Medical School of Yan'an University, Yan'an, China; Yan'an Key Laboratory of Neuroscience, Yan'an, China
Yunhang Jing
Medical School of Yan'an University, Yan'an, China; Yan'an Key Laboratory of Neuroscience, Yan'an, China; Imagining Department, Yan'an University Affiliated Hospital, Yan'an, China
Xinyue Bai
Medical School of Yan'an University, Yan'an, China; Yan'an Key Laboratory of Neuroscience, Yan'an, China
Mengze He
Medical School of Yan'an University, Yan'an, China; Yan'an Key Laboratory of Neuroscience, Yan'an, China
Qingyan Wang
Medical School of Yan'an University, Yan'an, China; Yan'an Key Laboratory of Neuroscience, Yan'an, China
Huilin Xi
Medical School of Yan'an University, Yan'an, China; Yan'an Key Laboratory of Neuroscience, Yan'an, China
Rui Shi
Department of Geriatrics Cardiology, The Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, China
Yanling Yang
Medical School of Yan'an University, Yan'an, China; Yan'an Key Laboratory of Neuroscience, Yan'an, China; Corresponding author. Medical School of Yan'an University, No. 580 Shengdi Road, Yan'an City, Shaan'xi 716000, China.
Background: Neurofilaments are neuron specific skeleton proteins maintaining axon transduction speed, leaked into cerebrospinal fluid and serum after axonal injury or neuron death. Sleep duration change has long related to many health issues but lack laboratory examination. Methods: This study enrolled total 10,175 participants from 2013 to 2014 National Health and Nutrition Examination Survey and used a multi-variable linear model to analyze the relationship between sleep duration and serum neurofilament light chain (sNfL) level. Results: There was a fixed relationship between sleep duration and sNfL level (β = 0.65, p = 0.0280). After adjusted for covariates, this relationship still (β = 0.82, p = 0.0052). Segmented regression showed that the turning point of sleep duration was 7 h 1 h decrease in sleep duration was significantly associated with −1.26 higher sNfL level (95 % CI: 2.25, −0.28; p = 0.0115) when sleep duration 7 h. Furthermore, the stratified analysis indicated that the associations between sleep duration and sNfL level were stronger among those normal body mass index and trouble sleeping (p-interaction <0.0001 and 0.0003). Conclusion: In summary, there was a J-shaped relationship between sleep duration and sNfL level in the United States of America representative group, these may suggest that extreme sleep duration can be deleterious judged by sNfL level. And still need large cohort study to determine the accurate relationship, and cluster analysis to infer the nervous disease connected with extreme sleep duration.
